FAF1 and FAF2 enhance human p97-UFD1-NPL4 complex unfoldase activity enabling rational design of p97 activators
Pritha Dasgupta, Ian R. Kelsall, Gaurav Anand, Anna Pérez‐Ràfols, Axel Knebel, Robert Gourlay, Glenn Robert Masson, Yogesh Kulathu
This study identifies FAF2 as a strong activator of the p97-UN complex and uses its mechanism to design de novo proteins that enhance p97 activity.
bioRxiv · Feb 25, 2026 · PreprintBiochemistry