Yogesh Kulathu

This paper identifies the EF-hand domain of MINDY3 as a ubiquitin and RAD23 UBL-binding domain, revealing its role in DNA damage response regulation.

The paper systematically identifies SLiM-binding interactions of USP family auxiliary domains using proteomic and biochemical methods, revealing functional redundancy and motif specificity.

This study identifies FAF2 as a strong activator of the p97-UN complex and uses its mechanism to design de novo proteins that enhance p97 activity.

The paper identifies a conserved selective autophagy receptor, CESAR, critical for proteostasis under heat stress in plants through cross-species interactome analysis.

This study shows ATXN3 helps restore lysosomal function after damage by targeting K48-K63-branched ubiquitin chains on regenerating lysosomes.

The paper identifies UFMylation of MRE11 as critical for telomere length and hematopoietic stem cell survival, showing its role in telomere maintenance without affecting DNA repair.