Anna Pérez‐Ràfols

This study identifies FAF2 as a strong activator of the p97-UN complex and uses its mechanism to design de novo proteins that enhance p97 activity.

The paper uses structural biology and computational methods to design MSI-1 mutants that alter RNA binding selectivity, validated by NMR and SPR experiments.

This study identifies a ubiquitin-binding domain in SPRTN that enhances its proteolytic activity towards polyubiquitinated DNA-protein crosslinks.

This paper engineers a bacterial gene regulation system using the mammalian RNA-binding protein Musashi-1 to repress translation through an allosteric mechanism.

This study shows that tanshinone mimics inhibit HuR-RNA interactions, reducing LPS-induced inflammation in macrophages by decreasing cytokine and chemokine expression.