Endogenous FGFs drive ERK-dependent cell fate patterning in 2D human gastruloids
Kyoung Jo, Zong-Yuan Liu, Gauri Patel, Zhiyuan Yu, LiAng Yao, Seth Teague, Craig N. Johnson, J R Spence, Idse Heemskerk
This study identifies FGF-dependent ERK signaling as critical for PS-like differentiation in 2D human gastruloids, driven by FGF4/17 and modulated by FGF8.
Development · Jan 12, 2026Peer-reviewedDevelopmental Biology