Kyoung Jo

This study identifies FGF-dependent ERK signaling as critical for PS-like differentiation in 2D human gastruloids, driven by FGF4/17 and modulated by FGF8.

The paper extends the culture of 2D gastruloids to 96h, revealing a phase of mesoderm differentiation with spatial organization similar to embryos.

The paper shows that the time integral of BMP signaling determines cell fate in human pluripotent stem cells, with duration and level of signaling being interchangeable in this context.

The paper demonstrates that geometric control of human pluripotent stem cells with BMP4 leads to efficient differentiation into hPGC-like cells, revealing NODAL signaling's critical role and improving differentiation efficiency.