Idse Heemskerk

This study identifies APLNR as a regulator of directed mesoderm migration in human gastruloids, showing chemotactic guidance through an epithelial ligand field.

The paper shows that a single snapshot of combinatorial signaling can predict cell fate in human embryonic patterning using Sig2Fate, a method combining immunofluorescence, information theory, and machine learning.

This study identifies FGF-dependent ERK signaling as critical for PS-like differentiation in 2D human gastruloids, driven by FGF4/17 and modulated by FGF8.

The paper extends the culture of 2D gastruloids to 96h, revealing a phase of mesoderm differentiation with spatial organization similar to embryos.

The paper shows that glycolytic activity regulates germ layer proportions by modulating Nodal and Wnt signalling in mouse gastrulation.

The paper shows that the time integral of BMP signaling determines cell fate in human pluripotent stem cells, with duration and level of signaling being interchangeable in this context.

This study develops iPSC-derived lung bud tip progenitor organoids that can be expanded and differentiated into airway or alveolar organoids, showing transcriptional similarity to in vivo progenitors.

The paper demonstrates that geometric control of human pluripotent stem cells with BMP4 leads to efficient differentiation into hPGC-like cells, revealing NODAL signaling's critical role and improving differentiation efficiency.

The paper shows Nodal is a short-range morphogen in human gastruloids, spreading via a relay mechanism and regulated by Lefty.

This paper develops an in vitro model of human ectodermal patterning using hESCs that self-organize into patterns mimicking the dorsal-ventral axis, revealing the role of WNT and BMP signaling in fate decisions.

This study shows that morphogen dynamics, not just concentration, control cell fate decisions in human embryonic stem cells during gastrulation.

The paper shows that BMP4 signaling in hESCs leads to single cell fates above a threshold in colonies, while requiring secondary signals and specific densities in standard conditions, with community effects enhancing response to external signals.