Craig N. Johnson

The paper shows that a single snapshot of combinatorial signaling can predict cell fate in human embryonic patterning using Sig2Fate, a method combining immunofluorescence, information theory, and machine learning.

This study shows KRT16 inhibits type I interferon signaling and innate immunity in skin diseases, providing new insights into inflammatory skin disorder mechanisms.

This study investigates the roles of PlexinA2, PlexinA4, and NCAM in the development of mossy fibers in the hippocampus, revealing distinct and overlapping functions in axon bundling and targeting.

This study identifies FGF-dependent ERK signaling as critical for PS-like differentiation in 2D human gastruloids, driven by FGF4/17 and modulated by FGF8.

The paper shows that K15 promotes a progenitor cell state in skin epidermis by counteracting K14's suppression of YAP1, a Hippo signaling effector.

This study identifies KRT9 as a regulator of YAP1 mechanosensitive signaling in palmoplantar epidermis, showing its role in maintaining skin identity and potential therapeutic targets for pEDDs.

This study investigates the roles of Gli2 and Gli3 in hair follicle development using mouse mutants, finding that Gli2 and Gli3 have specific and redundant functions in cell fate determination and cilia-dependent signaling.

AxoMetric quantifies axon regeneration in tissue sections with speed and accuracy, matching manual methods while enabling high-throughput analysis.

The paper extends the culture of 2D gastruloids to 96h, revealing a phase of mesoderm differentiation with spatial organization similar to embryos.

The paper shows that the time integral of BMP signaling determines cell fate in human pluripotent stem cells, with duration and level of signaling being interchangeable in this context.

The paper creates an atlas of injured sciatic nerve cells and identifies immune microenvironments and communication networks in mouse nerve regeneration.

The paper reanalyzes single-cell RNA-seq data to confirm and extend understanding of keratin gene expression patterns in epithelial tissues.

This study identifies efferocytosis as a key mechanism for nerve debridement following sciatic nerve injury through single-cell RNA-sequencing and genetic analysis.

This study shows that shRNAs cause microRNA dysregulation and global transcriptomic changes in neurons, independent of their target.