Localized APP pathology in the hippocampus is sufficient to result in progressive disorganization of the timing of neuronal firing patterns
Silvia Viana da Silva, Matthias Georg Haberl, Kshitij Gaur, Rina Patel, Gautam Narayan, Max Ledakis, Maylin L. Fu, Edward H. Koo, Jill K. Leutgeb, Stefan Leutgeb
This study shows that localized APP pathology in hippocampal CA3 cells leads to altered neuronal firing patterns in connected regions, suggesting disease progression can occur through physiological dysfunction rather than just spreading pathology.
bioRxiv · Oct 24, 2022 · PreprintNeuroscience