Silvia Viana da Silva

Deep mapping of the endomembrane system of cerebellar Purkinje neurons

The paper maps the endomembrane system of cerebellar Purkinje neurons using electron microscopy, revealing cell-type-specific and subcellular structural organization of organelles.

Inhibitory and excitatory cFos engram neurons are preferentially reactivated by sharp wave ripples

The paper identifies that cFos engram neurons, including place cells and interneurons, are preferentially reactivated during sharp wave ripples, linking engram identity to hippocampal network dynamics during memory consolidation.

Localized APP pathology in the hippocampus is sufficient to result in progressive disorganization of the timing of neuronal firing patterns

This study shows that localized APP pathology in hippocampal CA3 cells leads to altered neuronal firing patterns in connected regions, suggesting disease progression can occur through physiological dysfunction rather than just spreading pathology.

Aβ-induced synaptic injury is mediated by presynaptic expression of amyloid precursor protein (APP) in hippocampal neurons

This study shows that Aβ-induced synaptic injury in hippocampal neurons is mediated by presynaptic APP expression, as demonstrated by orientation-specific LTP reduction and synaptic loss.