Author

Gean Hu

University of California, Berkeley

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cell Biology· 2 Synthetic Biology· 1

Signature Assays, Organisms & Methods

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Organism:yeast· 3 Approach:experimental assay· 2 Research Focus:cell signaling & trafficking· 1 Research Focus:cell type annotation· 1 Approach:machine learning (classical)· 1 Approach:microscopy & imaging analysis· 1 Research Focus:protein design· 1 Assay:protein sequence· 1

Frequent Co-Authors

David G. DrubiniD· 2 shared Yidi SuniD· 2 shared Aditya Udupa· 1 shared Albert Yeam· 1 shared Aline TschanziD· 1 shared Andrew Wong· 1 shared Angelica W. Y. Lam· 1 shared Claire J. LeBlanc· 1 shared

Activity by Year

2026-2026 · peak 3/yr

Co-Author Collaboration Network

10 top collaborators · 18 mutual co-author links

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2 shared papersCell Biology

David G. DrubinORCID

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Author profile →

3 papers

Recent·Most cited

Machine learning guided design of strong transcriptional activation domains

Marissa A. Zintel, Claire J. LeBlanc, Sanjana R. Kotha, Melvin Soriano, Rishaan J. Bansal, Daniel Aguilera, Touss Majidi, Izaiah Ornelas, Liam D. Kirkpatrick, Aditya Udupa, Gean Hu, Pooja Agarwal, Angelica W. Y. Lam, James K. Nunez, Patrick M. Shih, , Max V. Staller

The paper designs functional transcriptional activation domains using machine learning and experimental validation, finding that over 90% of predicted sequences work in yeast.

bioRxiv · Nov 2, 2026 · PreprintSynthetic Biology

Phosphoregulation of hierarchical protein condensate formation during clathrin-mediated endocytosis

Yidi Sun, Andrew Wong, Gean Hu, Albert Yeam, Katelyn Wong, Lucien Vu Dao, Aline Tschanz, David G. Drubin

This study identifies two biophysical classes of proteins involved in clathrin-mediated endocytosis and shows how phosphorylation modulates their condensation dynamics.

bioRxiv · Sep 22, 2026 · PreprintCell Biology

Polarized anionic phospholipids and exocytosis are implicated in the polarized recruitment of budding yeast AP180, an endocytic initiator

Paul Marchando, Gean Hu, Feng Yuan, Jordan Matthew Ngo, Yidi Sun, David G. Drubin

This study shows that Snc2 recruits Yap1802 to daughter cells, linking polarized secretion to CME initiation through anionic phospholipids.

Molecular Biology of the Cell · Apr 8, 2026Peer-reviewedCell Biology