This study identifies two biophysical classes of proteins involved in clathrin-mediated endocytosis and shows how phosphorylation modulates their condensation dynamics.

bioRxiv · Sep 22, 2026 · PreprintCell Biology

Polarized anionic phospholipids and exocytosis are implicated in the polarized recruitment of budding yeast AP180, an endocytic initiator

Paul Marchando, Gean Hu, Feng Yuan, Jordan Matthew Ngo, Yidi Sun, David G. Drubin

This study shows that Snc2 recruits Yap1802 to daughter cells, linking polarized secretion to CME initiation through anionic phospholipids.

Molecular Biology of the Cell · Apr 8, 2026Peer-reviewedCell Biology

Molecular Architecture and Function Mechanism of Tri-heteromeric GluN1-N2-N3A NMDA Receptors

Zengwei Kou, Fenyong Yao, Tongtong Zhang, Nan Song, Chun Xie, B M Wang, Yidi Sun

This study determines the structure and activation mechanism of GluN1-N2A-N3A tri-heteromeric NMDA receptors using cryo-EM and electrophysiology.

bioRxiv · Aug 25, 2025 · PreprintNeuroscience

BrainBeacon: A Cross-Species Foundation Model for Single-cell Resolved Brain Spatial Transcriptomics

Chengming Zhang, Yiwen Yang, Yifeng Jiao, Qianqian Yang, Xin Guo, Jing Xu, Jiyang Li, Yuanyuan Zhou, Zhen Liu, Yushuai Wu, Yu Zhang, Jiang Chen, Jianyun Ma, Yuxuan Liu, Yao Zhang, , Wu Wei

BrainBeacon is a cross-species foundation model for whole-brain spatial transcriptomics that enables cross-species alignment and uncovers spatial regulatory mechanisms of aging.

bioRxiv · Jul 8, 2025 · PreprintBioinformatics