David G. Drubin

This study investigates how protein droplet capillary forces regulate clathrin-mediated endocytosis by stalling and then driving membrane invagination.

This study identifies two biophysical classes of proteins involved in clathrin-mediated endocytosis and shows how phosphorylation modulates their condensation dynamics.

The paper introduces MOSAIC, a multimodal adaptive optical microscope that enables non-invasive imaging across biological scales in live specimens.

This study shows that Snc2 recruits Yap1802 to daughter cells, linking polarized secretion to CME initiation through anionic phospholipids.

This study shows that Myosin1E adapts to increased membrane tension by recruiting to more clathrin-mediated endocytosis sites to enhance actin network formation and promote internalization.

This paper uses cell fusion to rapidly generate genome-edited human cells expressing fluorescent fusion proteins, revealing novel protein-organelle interactions.

The paper uses computational models to show that force-insensitive myosin-I enhances endocytosis robustness by reducing pit retraction, rather than through direct force transduction.

This study shows that intersectin1 promotes clathrin-mediated endocytosis by organizing and stabilizing endocytic protein interaction networks rather than initiating CME.

The paper investigates the role of actin filament crosslinking proteins in force generation during clathrin-mediated endocytosis in yeast, showing that increased crosslinking enhances internalization under high turgor pressure.

The paper develops a method to image subcellular dynamics in vivo using lattice light sheet microscopy and adaptive optics, revealing phenotypic diversity across organisms and developmental stages.