Rheb membrane orientation dynamics and functional consequences elucidated by molecular simulations, single-molecule-FRET and signaling assays
Chase M. Hutchins, Cynthia V. Pagba, Geetika Verma, Jacob L. Jakubec, Guangwei Du, Vasanthi Jayaraman, Alemayehu Abebe Gorfe
This study uses simulations and assays to show Rheb switches between membrane orientations, affecting mTORC1 activity.
bioRxiv · Mar 2, 2026 · PreprintBiophysics