Human SHED-derived extracellular cues activate a specialized neuroprotective and regenerative program in developing retinal ganglion cells
Marian Mellén, Gema Garcia-Guirado, Laura Botana, Enrique Calvo, Yariliz Sencion, Mattia Biondo, Javier Díez-Mata, J P Fernández Vázquez, Ismael Santa‐María, Maite Iglesias
This study shows that SHED-derived extracellular factors enhance axonal regeneration and neuronal survival in retinal ganglion cells through distinct paracrine mechanisms.
bioRxiv · Jun 26, 2026 · PreprintCell Biology