Ismael Santa‐María

This study shows that SHED-derived extracellular factors enhance axonal regeneration and neuronal survival in retinal ganglion cells through distinct paracrine mechanisms.

The paper shows that Ngfr promotes neurogenesis and reduces amyloid pathology in AD mouse models by suppressing Lcn2/Slc22a17 signaling.

The paper analyzes RNA-seq data from Caribbean-Hispanic Alzheimer's patients and controls to identify ancestry-specific gene expression patterns associated with disease.

The paper investigates the impact of the EphA1 P460L mutation on Rho-GTPase signaling in Alzheimer's disease, showing it leads to constitutive receptor activity and dysregulated signaling.

This study shows NSun2 deficiency in AD leads to miR-125b dysregulation and tau hyperphosphorylation, promoting neurodegeneration through epitranscriptomic mechanisms.

This study shows that targeting GPCRs to enhance synaptic proteasome activity reduces tau accumulation and cognitive decline in a mouse model of Alzheimer's disease.

This study shows miR-219 deficiency contributes to AD by dysregulating tau-kinase network through post-transcriptional mechanisms, leading to neurodegeneration and memory issues.