Computational insights into mechanism of AIM4-mediated inhibition of aggregation of TDP-43 protein implicated in ALS and evidence for in vitro inhibition of liquid-liquid phase separation (LLPS) of TDP-432C-A315T by AIM4.
Amandeep Girdhar, Vidhya Bharathi, Vikas Ramyagya Tiwari, Suman Abhishek, Waghela Deeksha, Usha Mahawar, Gembali Raju, Sandeep K. Singh, Ganesan Prabusankar, Eerappa Rajakumara, Basant Kumar Patel
This study uses computational methods to identify AIM4's binding site on TDP-43 and shows it inhibits LLPS of a TDP-43 mutant in vitro.
International Journal of Biological Macromolecules · Jan 7, 2020Peer-reviewedBioinformatics