Vidhya Bharathi

Enhanced in vitro aggregation, but not phase separation, of TDP-43 and its C-terminal fragments generate deep-blue autofluorescence.

This study shows that enhanced in vitro aggregation of TDP-43 and its fragments generates deep-blue autofluorescence, which is not emitted by phase-separated structures or oligomers.

Role of CNC1 gene in TDP-43 aggregation-induced oxidative stress-mediated cell death in S. cerevisiae model of ALS.

The paper investigates the role of CNC1 gene in TDP-43 aggregation-induced oxidative stress-mediated cell death in a yeast model of ALS, finding that CNC1 deletion reduces TDP-43 toxicity.

Computational insights into mechanism of AIM4-mediated inhibition of aggregation of TDP-43 protein implicated in ALS and evidence for in vitro inhibition of liquid-liquid phase separation (LLPS) of TDP-432C-A315T by AIM4.

This study uses computational methods to identify AIM4's binding site on TDP-43 and shows it inhibits LLPS of a TDP-43 mutant in vitro.