BioinformaticsInternational Journal of Biological MacromoleculesPeer-reviewed
Computational insights into mechanism of AIM4-mediated inhibition of aggregation of TDP-43 protein implicated in ALS and evidence for in vitro inhibition of liquid-liquid phase separation (LLPS) of TDP-432C-A315T by AIM4.
Amandeep Girdhar, Vidhya Bharathi, Vikas Ramyagya Tiwari…·Basant Kumar Patel
This study uses computational methods to identify AIM4's binding site on TDP-43 and shows it inhibits LLPS of a TDP-43 mutant in vitro.
56 citations