Inhibition of LRRK2 kinase activity rescues deficits in striatal dopamine dynamics in VPS35 p.D620N knock-in mice
Mengfei Bu, Jordan Follett, Igor Tatarnikov, Shannon C. Wall, Dylan T. Guenther, Isaac Bul Deng, Genevieve Wimsatt, Austen J. Milnerwood, Mark S. Moehle, Habibeh Khoshbouei, Matthew James Farrer
The paper shows that inhibiting LRRK2 kinase activity rescues dopamine deficits in VPS35 p.D620N knock-in mice by normalizing DAT function and reducing hyperlocomotion.
bioRxiv · May 14, 2023 · PreprintNeuroscience