Isaac Bul Deng

Vps35 p.D620N causes Lrrk2 kinase hyperactivity, chronic microglial activation and inflammation

This study investigates the effects of Vps35 p.D620N mutation on microglial function, showing increased LRRK2 kinase activity, chronic inflammation, and altered immune responses in mice.

Bidirectional disruption of Lrrk2 function drives T cell dysregulation and an exhaustion-like immune response

This study shows that disrupting Lrrk2 function in both directions leads to T cell dysregulation and exhaustion-like immune responses in mice.

Peripheral inflammation mediates midbrain Lrrk2 kinase activity via Rab32 expression

This study identifies Rab32 as a mediator linking peripheral inflammation to Lrrk2 kinase activity in microglia, with Tfe3 regulating Rab32 expression and Lrrk2 activation.

Characterization of Dnajc12 knockout mice, a model of hypodopaminergia

This study characterizes Dnajc12 knockout mice, showing reduced dopamine and serotonin levels, altered behavior, and potential therapeutic implications for biogenic amine disorders.

Inhibition of LRRK2 kinase activity rescues deficits in striatal dopamine dynamics in VPS35 p.D620N knock-in mice

The paper shows that inhibiting LRRK2 kinase activity rescues dopamine deficits in VPS35 p.D620N knock-in mice by normalizing DAT function and reducing hyperlocomotion.