Author

Mengfei Bu

National Institutes of HealthORCID 0000-0003-3045-652XUnclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

Click to filter author papers

Signature Assays, Organisms & Methods

Click to filter · or open tag

Organism:mouse· 2 Assay:bulk RNA-seq· 1 Research Focus:differential expression· 1 Approach:experimental assay· 1 Approach:statistical model· 1

Frequent Co-Authors

Isaac Bul DengiD· 2 shared Jordan FollettiD· 2 shared Matthew James FarreriD· 2 shared Shannon C. Wall· 2 shared Adamantios MamaisiD· 1 shared Austen J. MilnerwoodiD· 1 shared Dylan T. GuentheriD· 1 shared Fahong YuiD· 1 shared

Activity by Year

2023-2026 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 36 mutual co-author links

Click any collaborator node to inspect or filter shared papers

Focal author (center)Selected co-authorORCID co-authorUnlinked name

Curved chords = mutual co-authorship

2 shared papersNeuroscience

Isaac Bul DengORCID

Mutual co-authors in cluster

Author profile →

2 papers

Recent·Most cited

Vps35 p.D620N causes Lrrk2 kinase hyperactivity, chronic microglial activation and inflammation

Isaac Bul Deng, Mengfei Bu, Jordan Follett, Robert C. Sharp, Adamantios Mamais, Leyna Xoi, Fahong Yu, Georges Rabil, Shannon C. Wall, Matthew James Farrer

This study investigates the effects of Vps35 p.D620N mutation on microglial function, showing increased LRRK2 kinase activity, chronic inflammation, and altered immune responses in mice.

bioRxiv · Sep 3, 2026 · PreprintNeuroscience

Inhibition of LRRK2 kinase activity rescues deficits in striatal dopamine dynamics in VPS35 p.D620N knock-in mice

Mengfei Bu, Jordan Follett, Igor Tatarnikov, Shannon C. Wall, Dylan T. Guenther, Isaac Bul Deng, Genevieve Wimsatt, Austen J. Milnerwood, Mark S. Moehle, Habibeh Khoshbouei, Matthew James Farrer

The paper shows that inhibiting LRRK2 kinase activity rescues dopamine deficits in VPS35 p.D620N knock-in mice by normalizing DAT function and reducing hyperlocomotion.

bioRxiv · May 14, 2023 · PreprintNeuroscience