Sequential Molecular Interactions Shape Aβ42 Aggregation, Propagation, and Toxicity
Jofre Seira Curto, Genis Perez Collell, Manuel Ruiz, Sandra Villegas, M. Rosario Fernández, Natalia Sánchez de Groot
The paper investigates how sequential molecular interactions modulate Aβ42 aggregation properties and toxicity across successive cycles, showing that early interactions with exogenous peptides alter aggregate characteristics and propagation.
bioRxiv · Sep 1, 2026 · PreprintBiochemistry