Jofre Seira Curto

Sequential Molecular Interactions Shape Aβ42 Aggregation, Propagation, and Toxicity

The paper investigates how sequential molecular interactions modulate Aβ42 aggregation properties and toxicity across successive cycles, showing that early interactions with exogenous peptides alter aggregate characteristics and propagation.

Exogenous Amyloid Sequences: Their Role in Amyloid-Beta Heterotypic Aggregation

The paper investigates how exogenous amyloid sequences from gut microbiota affect Aβ heterotypic aggregation and introduces the 'Interaction History' concept.

Microbiome-Derived Prion-Like Proteins and Their Potential to Trigger Cognitive Dysfunction

The paper shows that 63% of gut microbiome proteins have prion-like sequences that can form amyloid fibrils, impair memory in C. elegans, and may contribute to neurodegenerative diseases.