Natalia Sánchez de Groot

The paper investigates how sequential molecular interactions modulate Aβ42 aggregation properties and toxicity across successive cycles, showing that early interactions with exogenous peptides alter aggregate characteristics and propagation.

This paper introduces catGRANULE 2.0 ROBOT, an algorithm predicting protein LLPS at single amino acid resolution, showing high performance and experimental validation.

The paper investigates how exogenous amyloid sequences from gut microbiota affect Aβ heterotypic aggregation and introduces the 'Interaction History' concept.

The paper shows that 63% of gut microbiome proteins have prion-like sequences that can form amyloid fibrils, impair memory in C. elegans, and may contribute to neurodegenerative diseases.

PRALINE is a database that catalogs proteins and RNAs in biological condensates, their interactions, and the impact of single-nucleotide variants on condensate properties.

The paper investigates the structural properties of proteins and RNAs in stress granules and processing bodies, finding that intrinsic disorder and single-stranded regions mediate dynamic interactions.

The paper investigates how Prion-Like Domains (PrLDs) and RNA-Binding Domains (RBDs) contribute to biomolecular condensation in human and yeast proteomes.

The paper quantifies the fitness costs and benefits of protein deposit formation via phase separation in yeast, showing environmental and functional demands influence fitness outcomes and generate phenotypic variability.

The paper investigates how RNA structure influences protein interactions, showing that structured RNA competes with protein binding and alters interaction networks.