Marian Kalocsay

Receptor-proximal phosphoform organization precedes β2 integrin activation

The paper quantifies phosphoform organization near β2 integrins and shows that signaling alters phosphosites while preserving spatial organization of proteins.

K63-linked ubiquitin chains mark inactive Smoothened for packaging into ciliary extracellular vesicles

The paper identifies K63-linked ubiquitin chains as a sorting signal for ciliary ectocytosis, showing that ubiquitinated inactive Smoothened is packaged into ciliary extracellular vesicles.

In situ Proteomics Unveils Specialized Domains for Extrasynaptic Signaling on Neuronal Cilia

The paper uses in situ proteomics to show neuronal cilia have specialized nanodomains for extrasynaptic signaling, enriched in synaptic proteins and neurotransmitter receptors.

Tubulin Regulates the Stability and Localization of STMN2 by Binding Preferentially to Its Soluble Form

This study shows STMN2 stabilizes by binding to tubulin, reducing its membrane localization and degradation, and proposes its neuroprotective role depends on its membrane-bound form.

Transitions in the proteome and phospho-proteome during early embryonic development in Xenopus

The paper analyzes proteome and phospho-proteome changes during Xenopus embryonic development, identifying key transitions in protein expression and phosphorylation patterns.

Catalytic pocket of Clr4 (Suv39h) methyltransfer-ase serves as a substrate receptor for Cullin 4-dependent histone H3 ubiquitination

This study shows that the catalytic pocket of Clr4 (Suv39h) acts as a receptor for Cul4-dependent H3K14 ubiquitination, which regulates Clr4's methylation activity on H3K9.

BBSome-Mediated Clearance of Ubiquitinated IMPG2 Defines a Constitutive Ciliary Retrieval Pathway in Photoreceptors

This study identifies IMPG2m as a BBSome cargo in photoreceptors, revealing a constitutive ciliary retrieval pathway involving ubiquitinated membrane proteins.

FGF13 regulates cardiomyocyte impulse propagation via Cx43 trafficking independent of voltage-gated sodium channels

This study shows FGF13 regulates Cx43 trafficking and cardiac impulse propagation without involving voltage-gated sodium channels.

Probing the CaV1.2 interactome in heart failure identifies a positive modulator of inotropy and lusitropy

The paper uses proximity proteomics to study the cardiac dyad in heart failure, identifying Galectin-1 as a positive modulator of cardiac contractility and relaxation.

Acute BRCAness Induction and AR Signaling Blockage through CDK12/7/9 Degradation Enhances PARP Inhibitor Sensitivity in Prostate Cancer

This paper introduces BSJ-5-63, a PROTAC that degrades CDK12, CDK7, and CDK9, inducing BRCAness and blocking AR signaling to enhance PARP inhibitor sensitivity in prostate cancer.

Structural Diversity and Dynamics of Metabotropic Glutamate Receptor/Beta-Arrestin Coupling

This study investigates the structural and dynamic diversity of metabotropic glutamate receptor/beta-arrestin coupling using biophysical and structural methods, revealing new coupling stoichiometries and interaction mechanisms.

TYK2 as a novel therapeutic target in Alzheimer Disease

The paper identifies TYK2 as a potential therapeutic target for neurodegenerative diseases by linking cdsRNA-induced inflammation to interferon signaling and demonstrating protective effects of TYK2 inhibitors.

HUWE1 Amplifies Ubiquitin Modifications to Broadly Stimulate Clearance of Proteins and Aggregates

This paper identifies HUWE1 as a ubiquitin ligase that enhances ubiquitin modifications on proteins and aggregates, promoting their degradation via proteasome and autophagy pathways.

A Spatiotemporal Notch Interaction Map from Membrane to Nucleus

This study maps the spatiotemporal dynamics of Notch2 signaling from membrane to nucleus after ligand activation, identifying key molecular events in signal transmission.

An RNA Degradation Complex Required for Spreading and Epigenetic Inheritance of Heterochromatin

The paper identifies the rixosome, an RNA degradation complex, as essential for heterochromatin spreading and epigenetic inheritance by degrading heterochromatic RNAs.

An RNA degradation complex required for silencing of Polycomb target genes

The paper shows the rixosome, an RNA degradation complex, associates with human PRC complexes and is required for silencing Polycomb target genes.

The protein repertoire in early vertebrate embryogenesis

The paper presents a comprehensive characterization of protein dynamics in Xenopus laevis early development and provides a web-based resource for data exploration.