Alberto J. Gonzalez-Hernandez

This study investigates the structural and dynamic diversity of metabotropic glutamate receptor/beta-arrestin coupling using biophysical and structural methods, revealing new coupling stoichiometries and interaction mechanisms.

Chromatin regulators including EZH2, EHMT1/2, and DOT1L establish an epigenetic barrier in human neural progenitors that poises maturation genes and sets the protracted pace of cortical neuron maturation.

The paper identifies novel regulators of mu opioid receptor signaling and trafficking using proximity labeling and proteomics.

The paper shows that BK channels suppress NMDAR activity in barrel cortex neurons, preventing spike-timing-dependent plasticity.