Intrinsic mechanotransduction during apical constriction licenses lineage competence in pluripotent stem cells
Mehdi S. Hamouda, Céline Labouesse, George W. Wylde, Daniel Yamamoto, Yekaterina A. Miroshnikova, Srinjan Basu, Clare M. Waterman, Kevin J. Chalut
This study shows that mechanical forces during epithelialization in pluripotent stem cells drive nuclear changes that prime neuroectodermal lineage commitment.
bioRxiv · Nov 3, 2025 · PreprintCell Biology