Author
Srinjan Basu
Wellcome/MRC Cambridge Stem Cell InstituteORCID 0000-0002-1080-979XUnclaimed ORCID profile · follow to get notified of new preprints
Biology Disciplines
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2022-2026 · peak 4/yrCo-Author Collaboration Network
10 top collaborators · 42 mutual co-author links8 papers
Recent·Most cited
- Developmental BiologybioRxivPreprint
Organoids reveal niche-specific mechanotransduction-guided human cortical patterning and cell fate acquisition
Alex J Kingston, Annabelle Wurmser, Aditi Kulkarni…·Srinjan Basu
This study uses organoids to show that disrupting the LINC complex affects human cortical cell fate and organization by altering mechanosensing and nuclear mechanics.
- Cell BiologybioRxivPreprint
Protein-protein interactions drive differences in the spatiotemporal dynamics of transcription factors NANOG and SOX2 in naïve pluripotent cells
Gökçe G. Agsu, Yuze Cao, Diyan Jain…·Srinjan Basu
The paper tracks SOX2 and NANOG dynamics in live cells using advanced microscopy and analysis pipelines, revealing differences in their spatiotemporal behavior due to protein-protein interactions.
DOI 10.64898/2025.12.03.691924 - Cell BiologybioRxivPreprint
Intrinsic mechanotransduction during apical constriction licenses lineage competence in pluripotent stem cells
Mehdi S. Hamouda, Céline Labouesse, George W. Wylde…·Kevin J. Chalut
This study shows that mechanical forces during epithelialization in pluripotent stem cells drive nuclear changes that prime neuroectodermal lineage commitment.
- BiochemistrybioRxivPreprint
Structure of ER chaperone complex GRP170-ATP-BiP suggests a new model for substrate engagement
Yassin Ben-Khoud, Kono Washio, Srinjan Basu, Maruf M. U. Ali
The paper reports the cryo-EM structure of the GRP170-ATP-BiP complex, revealing a new model for substrate engagement and GRP170's pseudo-ATPase activity.
- Cell BiologybioRxivPreprint
Non-catalytic role for MLL2 in controlling chromatin organisation and mobility during priming of pluripotent cells for differentiation
M. Steindel, Oliver Davis, Katrin Neumann…·Srinjan Basu
This study shows MLL2 stabilizes 3D chromatin loops during pluripotent cell differentiation without requiring its enzymatic activity.
- Molecular BiologyNature Structural & Molecular BiologyPeer-reviewed
H4K16ac activates transcription of transposable elements and contribute to their cis regulatory function
Debosree Pal, Manthan Patel, Fanny Boulet…·Madapura M. Pradeepa
The paper shows H4K16ac activates LINE1 and LTR transcription, contributing to cis-regulatory function by maintaining active chromatin at TEs.
75 citationstop 2% - Molecular BiologyNature CommunicationsPeer-reviewed
Satellite repeat transcripts modulate heterochromatin condensates and safeguard chromosome stability in mouse embryonic stem cells
Clara Lopes Novo, Emily V. Wong, Colin Hockings…·Peter J. Rugg‐Gunn
This study shows that satellite repeat transcripts in mouse ESCs drive heterochromatin condensates, which are crucial for chromosome stability and nuclear organization.
62 citationstop 4%