Kevin J. Chalut

This study shows that collagen I mechanical signaling in synthetic hydrogels promotes cholangiocyte differentiation and bile duct formation from hiPSCs.

This study shows basement membrane mechanics regulate the spatial response to BMP4 in hPSCs and mouse embryos, disrupting gastrulation patterning when mechanics are altered.

The paper tracks SOX2 and NANOG dynamics in live cells using advanced microscopy and analysis pipelines, revealing differences in their spatiotemporal behavior due to protein-protein interactions.

This study shows that mechanical forces during epithelialization in pluripotent stem cells drive nuclear changes that prime neuroectodermal lineage commitment.

This study identifies how tissue mechanics and hyaluronic acid regulate digit tip regeneration by modulating ECM composition and cell behavior.

This study shows that cell-matrix forces increase during the loss of naive pluripotency in mESCs and are required for this process.

This study shows ERK signalling dismantles the naive pluripotent state and preserves pluripotency during transition to formative pluripotency in mouse embryonic stem cells.

This study shows that Plakoglobin regulates naive pluripotency in mouse ESCs through mechanosensitivity, with expression specific to the blastocyst stage in human and mouse embryos.

The paper identifies dynamic cell surface fluctuations as a key factor in early embryonic lineage sorting, showing that increased surface fluctuations in primitive endoderm precursors drive their segregation from epiblast precursors.