Decoding human sperm signalling: Phosphoproteomic discovery of kinases governing fertilization competency
Nathan D. Burke, Amanda L. Anderson, John Even Schjenken, Shaun D. Roman, Hanah M. Hart, Heather C. Murray, Kasey Miller, Georgia E. Blackley, R. John Aitken, David Anthony Skerrett-Byrne, Brett Nixon, Elizabeth G. Bromfield
The paper uses phosphoproteomic analysis to identify kinases involved in human sperm capacitation, finding PLK1 inhibition affects motility and acrosome reaction.
bioRxiv · Jun 23, 2026 · PreprintCell Biology