Heather C. Murray

This study evaluates (E,E)-bisantrene's anti-leukemic activity in AML by showing it suppresses MYC expression and induces apoptosis across multiple models.

The paper uses phosphoproteomic analysis to identify kinases involved in human sperm capacitation, finding PLK1 inhibition affects motility and acrosome reaction.

This study shows bisantrene enhances the effectiveness of tyrosine kinase inhibitors in ccRCC by sustaining AKT inhibition and overcoming TKI resistance.

This study shows that hypomethylating agents induce epigenetic and transcriptional heterogeneity in AML cells, with some cells retaining methylation and showing increased self-renewal, and identifies statins as a potential co-treatment to enhance HMA efficacy.

This study identifies SNPs in the nuclear genome associated with fetal growth restriction and mitochondrial complex I dysfunction, impacting placental bioenergetics and birthweight.

This study investigates iron utilization in placental tissues of fetal growth restriction (FGR) pregnancies, revealing increased iron uptake and prioritization of heme synthesis over iron-sulfur cluster formation.

This study identifies ATM-driven DNA repair and ROS addiction as mechanisms of resistance to FLT3 inhibitors in AML and shows ATM inhibition can overcome resistance in vitro and in vivo.