Brett Nixon

This study compares mitochondrial and metabolic properties of stem and progenitor cells in the male germline, finding that stem cells exhibit metabolic plasticity and latent oxidative capacity.

Deep proteome and phosphoproteome of Id4-eGFP-sorted mouse spermatogonial stem and progenitor cells reveal 8,464 proteins, poor RNA-protein concordance, and phosphorylation-driven kinase candidates tested functionally.

The paper uses phosphoproteomic analysis to identify kinases involved in human sperm capacitation, finding PLK1 inhibition affects motility and acrosome reaction.

This paper develops a nuclear transplantation protocol for Limnodynastes peronii, achieving the first confirmed nuclear transplantation in an Australian native frog.

This study shows that cell size affects cryopreservation outcomes in amphibian embryonic cells, with optimal cryoprotectant conditions varying by cell size.

This study identifies extensive phosphoproteomic remodeling in mouse sperm during maturation and capacitation, revealing key kinases and their roles in fertility.

This study integrates proteomic data from 12 vertebrate species to identify a core sperm proteome, revealing conserved molecular pathways and validating novel proteins critical for fertility.

This study shows that sub-chronic heat stress alters sperm small non-coding RNA profiles in mice, leading to accelerated embryonic development and fetal weight gain.

This study identifies ATM-driven DNA repair and ROS addiction as mechanisms of resistance to FLT3 inhibitors in AML and shows ATM inhibition can overcome resistance in vitro and in vivo.

This study shows how oocyte-secreted factors alter proteomic and metabolic profiles of oocytes and cumulus cells during maturation, enhancing their cooperativity for fertilization.