Identification of a VPS29 isoform with restricted association to Retriever and Retromer accessory proteins through auto-inhibition.
James L. Daly, Kai‐En Chen, Rebeka Butkovič, Qian Guo, Michael D. Healy, Eva Pennink, Georgia Gamble-Strutt, Zara Higham, Edmund R. R. Moody, Philip A. Lewis, Kate J. Heesom, Tom A. Williams, Kirsty J. McMillan, Brett M. Collins, Peter J. Cullen
The paper identifies a new VPS29 isoform, VPS29C, which exhibits auto-inhibition limiting its association with Retriever and Retromer accessory proteins, revealing new complexity in Retromer function.
Proceedings of the National Academy of Sciences · Jun 30, 2025Peer-reviewedCell Biology