Author

Qian Guo

The University of QueenslandORCID 0000-0002-2133-5358Unclaimed ORCID profile · follow to get notified of new preprints

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Qian Guo1 paper

Biology Disciplines

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Cell Biology· 5

Signature Assays, Organisms & Methods

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Approach:experimental assay· 4 Research Focus:cell type annotation· 3 Research Focus:cell signaling & trafficking· 2 Organism:human· 2 Assay:proteomics· 2 Organism:yeast· 2 Approach:biophysical modeling· 1 Research Focus:chromatin & epigenetic regulation· 1

Frequent Co-Authors

Brett M. CollinsiD· 5 shared Kai‐En CheniD· 4 shared Andreas MayeriD· 2 shared Kate J. HeesomiD· 2 shared Meihan LiuiD· 2 shared Michael D. HealyiD· 2 shared Peter J. CulleniD· 2 shared Philip A. LewisiD· 2 shared

Activity by Year

2025-2026 · peak 4/yr

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10 top collaborators · 33 mutual co-author links

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5 shared papersCell Biology

Brett M. CollinsORCID

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5 papers

Recent·Most cited

The GTPase activating protein Gyp6 binds Retromer and inactivates Rab7/Ypt7 to coordinate the formation of endosomal carriers

Ana Catarina Alves, Kai‐En Chen, Lydie Michaillat Mayer, Qian Guo, Ella J. Stephens, Meihan Liu, Michael D. Healy, Brett M. Collins, Andreas Mayer

This study identifies Gyp6 as a GAP that regulates Ypt7 activity through Retromer to coordinate endosomal carrier formation in yeast.

bioRxiv · Jan 27, 2026 · PreprintCell Biology

Mapping the endosomal proximity proteome reveals Retromer as a hub for RAB GTPase regulation.

Carlos Antón-Plágaro, Chen Kai-en, Qian Guo, Meihan Liu, Ashley J. Evans, Philip A. Lewis, Kate J. Heesom, Kevin A. Wilkinson, Brett M. Collins, Peter J. Cullen

The paper identifies Retromer as a hub for RAB GTPase regulation through proximity proteomics and biochemical analysis.

Nature Communications · Jul 30, 2025Peer-reviewedCell Biology

Identification of a VPS29 isoform with restricted association to Retriever and Retromer accessory proteins through auto-inhibition.

James L. Daly, Kai‐En Chen, Rebeka Butkovič, Qian Guo, Michael D. Healy, Eva Pennink, Georgia Gamble-Strutt, Zara Higham, Edmund R. R. Moody, Philip A. Lewis, Kate J. Heesom, Tom A. Williams, Kirsty J. McMillan, Brett M. Collins, Peter J. Cullen

The paper identifies a new VPS29 isoform, VPS29C, which exhibits auto-inhibition limiting its association with Retriever and Retromer accessory proteins, revealing new complexity in Retromer function.

Proceedings of the National Academy of Sciences · Jun 30, 2025Peer-reviewedCell Biology

Cavin1 binding nanobodies reveal structural flexibility and regulated interactions of the N-terminal coiled-coil domain

Ya Gao, Vikas A. Tillu, Yeping Wu, James A. Rae, Thomas Edward Hall, Kai‐En Chen, Saroja K. Weeratunga, Qian Guo, Emma K. Livingstone, Wai‐Hong Tham, Robert G. Parton, Brett M. Collins

The paper develops nanobodies that bind Cavin1's HR1 domain, revealing structural flexibility and regulated interactions important for caveolae assembly.

Journal of Cell Science · Apr 15, 2025Peer-reviewedCell Biology

Molecular basis for the assembly of the Vps5-Vps17 SNX-BAR proteins with Retromer

Kai‐En Chen, Vikas A. Tillu, Navin Gopaldass, Sudeshna Roy Chowdhury, Natalya Leneva, Oleksiy Kovtun, Juanfang Ruan, Qian Guo, Nicholas Ariotti, Andreas Mayer, Brett M. Collins

This study investigates how Vps5 and Vps17 SNX-BAR proteins assemble with Retromer, revealing a PL motif in Vps5 that binds Vps29 and is essential for membrane tubule association and cargo recycling.

Nature Communications · Apr 15, 2025Peer-reviewedCell Biology

Qian Guo · henhao