Author

James L. Daly

Guy's HospitalORCID 0000-0002-4551-1256Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Biophysics· 1 Cell Biology· 1 Neuroscience· 1

Signature Assays, Organisms & Methods

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Organism:human· 3 Assay:proteomics· 2 Assay:bulk RNA-seq· 1 Research Focus:cell type annotation· 1 Research Focus:cell-cell communication· 1 Approach:deep learning· 1 Approach:experimental assay· 1 Research Focus:gene regulatory network inference· 1

Frequent Co-Authors

Kate J. HeesomiD· 2 shared Peter J. CulleniD· 2 shared Philip A. LewisiD· 2 shared Alessia GentiliiD· 1 shared Andrea BallabioiD· 1 shared Brett M. CollinsiD· 1 shared Cecilia ZazaiD· 1 shared Chris M. Danson· 1 shared

Activity by Year

2023-2026 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 21 mutual co-author links

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2 shared papersCell Biology

Kate J. HeesomORCID

Mutual co-authors in cluster

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3 papers

Recent·Most cited

BiophysicsbioRxivPreprintOct 4, 2026

Gag proteolysis drives HIV-1 envelope conformational closure through the gp41 cytoplasmic tail

David J. Williamson, Cecilia Zaza, Irene Carlón-Andrés…·Sergi Padilla‐Parra

This study shows that Gag proteolysis drives HIV-1 Env conformational closure through the gp41 cytoplasmic tail, revealing a mechanism for immune evasion.

DOI 10.64898/2026.10.02.756164

humanimaging

Cell BiologyProceedings of the National Academy of SciencesPeer-reviewedJun 30, 2025

Identification of a VPS29 isoform with restricted association to Retriever and Retromer accessory proteins through auto-inhibition.

James L. Daly, Kai‐En Chen, Rebeka Butkovič…·Peter J. Cullen

The paper identifies a new VPS29 isoform, VPS29C, which exhibits auto-inhibition limiting its association with Retriever and Retromer accessory proteins, revealing new complexity in Retromer function.

6 citations

humanproteomics

NeuroscienceNature CommunicationsPeer-reviewedMay 29, 2023

Multiomic Approach Characterises the Neuroprotective Role of Retromer in Regulating Lysosomal Health

James L. Daly, Chris M. Danson, Philip A. Lewis…·Peter J. Cullen

The paper uses a multiomic approach to study Retromer's role in lysosomal health in human neuroglioma cells, revealing proteomic and transcriptomic changes linked to neurodegeneration.

42 citationstop 2%

humanproteomics