Philip A. Lewis

This study identifies copper as a key mediator in mutualistic interactions between Candida albicans and Staphylococcus aureus biofilms, showing non-reciprocal copper handling and therapeutic potential via copper nanoparticles.

The paper identifies neuronal and astrocytic membrane proteins dependent on Retromer for endosomal recycling, highlighting SNX27-Retromer's role in glutamate transporter trafficking.

This study identifies SPATS2L as a mediator of growth and survival in RUNX1-mutant blast-phase CML through stress granule formation, suggesting it as a therapeutic target.

This study identifies FDXR upregulation as a prognostic marker and therapeutic target in HTLV-1-associated ATL, showing its link to disease severity and sensitivity to fluorouracil.

This study identifies the RAB32-LRMDA-Commander complex and shows its role in melanosome biogenesis and pigmentation, revealing the mechanism of oculocutaneous albinism type 7.

The paper identifies Retromer as a hub for RAB GTPase regulation through proximity proteomics and biochemical analysis.

This study shows that GMAP210 and Golgin-160 have distinct roles in maintaining Golgi structure, both necessary for efficient ECM secretion and modification.

The paper identifies a new VPS29 isoform, VPS29C, which exhibits auto-inhibition limiting its association with Retriever and Retromer accessory proteins, revealing new complexity in Retromer function.

This study identifies RSS as a recyclinopathy caused by dysfunction in the Commander endosomal recycling pathway, linking it to multiple tissue malformations.

The paper uses a multiomic approach to study Retromer's role in lysosomal health in human neuroglioma cells, revealing proteomic and transcriptomic changes linked to neurodegeneration.

This study identifies LRFN2 as a new SNX27-dependent cargo that regulates AMPA receptor trafficking and synaptic function, revealing an indirect mechanism for SNX27's role in neurological conditions.