Engineering a ribozyme with aminoacyl-tRNA synthetase activity
Rui Gan, Chen Ji, Gerald Manuel, Hillary Andaluz Aguilar, W. Andy Tao, Robert M. Corn, Donald H. Burke, Andrej Lupták, Barbara L. Golden
This paper engineers a ribozyme that can aminoacylate tRNA and discriminate between cognate and non-cognate tRNAs, enabling non-canonical amino acid incorporation.
ACS Chemical Biology · Sep 26, 2026Peer-reviewedBiochemistry