Donald H. Burke

This paper engineers a ribozyme that can aminoacylate tRNA and discriminate between cognate and non-cognate tRNAs, enabling non-canonical amino acid incorporation.

This study identifies DUSP11 as an intracellular innate immune checkpoint in LUAD, showing its role in tumor survival and growth, and suggests it as a potential therapeutic target.

This study shows that an anti-EGFR aptamer reduces viability of NSCLC cells with EGFR L858R mutations and tumor burden in a mouse model, with cell line-dependent mechanisms.

This study identifies RNA aptamers specific to different HIV-1 capsid assembly forms, enabling their purification from cell lysates without virus or host modification.

FASTAptameR 2.0 provides a user-friendly web tool for analyzing combinatorial sequence selections with improved performance and features.

The paper evaluates a threose nucleic acid (TNA) oligonucleotide derived from a CpG sequence and finds it induces immune responses in B cell lines with minimal effects on proliferation.

The paper identifies broad-spectrum RNA aptamers that inhibit diverse primate lentiviral reverse transcriptases using a Poly-Target selection approach.

This paper introduces a split-aptamer system called Split-Broccoli that enables visualization of RNA-RNA assembly in vivo through fluorescence activation upon hybridization of two RNA strands.