Temporal control of axonal floor plate crossing through a combination of incoherent feedforward and feedback loops of gene regulatory network regulating Robo3 expression
Reut Sudakevitz-Merzbach, Madhuri Majumder, Gerard Elberg, Marah Bakhtan, Dina Rekler, Sophie Khazanov, Benjamin Joel Wheaton, Nissim Ben‐Arie, Gilgi Friedlander, Chaya Kalcheim, Sara Ivy Wilson, Alexander Jaworski, Miri Adler, Avihu Klar
The paper shows that Robo3 expression in spinal commissural neurons is controlled by gene regulatory networks involving incoherent feedforward and feedback loops, which determine midline crossing.
bioRxiv · Oct 26, 2025 · PreprintDevelopmental Biology