Chaya Kalcheim

The paper shows that Robo3 expression in spinal commissural neurons is controlled by gene regulatory networks involving incoherent feedforward and feedback loops, which determine midline crossing.

The paper uses single-cell RNA sequencing to map the developmental trajectory of dI1 spinal interneurons in quail, revealing stage-specific roles of retinoic acid and BMP signaling.

The paper investigates how retinoic acid influences the segregation of dorsal neural fates by analyzing gene expression and lineage markers in developing neural tubes.

This study shows that retinoic acid from the neural tube inhibits BMP signaling to end neural crest cell production and ensure proper roof plate formation.

The paper uses transcriptome analysis to identify genes involved in Notch-dependent roof plate formation and shows Notch signaling is critical for RP development and fate determination.

The paper shows that Shh from the sclerotome affects neural tube development by acting on the basal side of the neuroepithelium, influencing motoneuron numbers and myotome differentiation.