Alexander Jaworski

The paper investigates the evolutionary origin of NELL-Robo interactions and shows that dual-ligand responsiveness is conserved in chordates but not protostomes.

The paper shows that Robo3 expression in spinal commissural neurons is controlled by gene regulatory networks involving incoherent feedforward and feedback loops, which determine midline crossing.

The paper shows that multiple guidance factors, including Netrin-1 and Slit proteins, are required for proper axon bifurcation in the dorsal funiculus during spinal cord development.

The paper identifies WFIKKN2 as a bifunctional axon guidance cue that repels sensory axons via Nope and attracts motor axons through other DCC family receptors.

This study shows that Sod1G85R knock-in mice exhibit up-regulated cholesterol synthesis pathways and limited neurodegeneration, contrasting with severe TgSOD1G93A mice, suggesting lipid pathway dysregulation in ALS.