Rüdiger Klein

Developmental trajectories organize the assembly of valence circuits in the central amygdala

The paper identifies developmental trajectories that organize valence-specific circuit assembly in the central amygdala using single-cell profiling and molecular analysis.

Anle138b ameliorates pathological phenotypes in mouse and cellular models of Huntington's disease

Anle138b reduces mHTT aggregates and improves disease phenotypes in HD cell and mouse models.

Central amygdala Isl1 neurons control biting by integrating sensory and motivational signals

This study identifies CeAIsl1 neurons in the central amygdala that modulate biting behavior by integrating sensory and motivational signals in mice.

snRNA-seq of Huntington's disease mice reveals vulnerability profiles of cortical cell types

This study uses snRNA-seq to analyze cortical cell types in HD mice, revealing differential vulnerability and identifying ER-phagy as a protective pathway in HD.

Cortex Folding by Combined Progenitor Expansion and Adhesion-Controlled Neuronal Migration

The paper shows that combining progenitor expansion with adhesion-controlled neuronal migration enhances cortex folding in mice, leading to sulci and gyri formation.

Optogenetic restoration of neuron subtype-specific cortical activity ameliorates motor deficits in Huntington's Disease mice

The paper shows optogenetic activation of VIP-INs in HD mice restores motor function by normalizing activity in VIP-INs and CSPNs.

Food and water uptake are regulated by distinct central amygdala circuits revealed using intersectional genetics

The paper identifies distinct central amygdala circuits regulating food and water uptake using intersectional genetics and in vivo calcium imaging.

Nausea-induced suppression of feeding is mediated by central amygdala Dlk1 expressing neurons

This study identifies a novel neuronal population in the central amygdala that mediates nausea-induced feeding suppression through specific circuitry.

Expansion of the neocortex and protection from neurodegeneration by in vivo transient reprogramming

This study shows that transient Yamanaka factor expression during development expands the neocortex and improves cognitive function in mice, while intermittent expression in adult neurons protects against Alzheimer's disease features.

Genetically- and spatially-defined basolateral amygdala neurons control food consumption and social interaction

The paper identifies genetically and spatially distinct BLA neuron subpopulations and their roles in food consumption and social behavior.

Neuroprotective effects of hepatoma-derived growth factor in models of Huntington's disease

This study shows that hepatoma-derived growth factor (HDGF) has neuroprotective effects in Huntington's disease models by reducing mutant Huntingtin toxicity and aggregation.

Transcriptomics reveals amygdala neuron regulation by fasting and ghrelin thereby promoting feeding

The paper identifies CeA neuron clusters and shows that ghrelin and fasting activate appetitive neurons involved in feeding behavior.

Encoding of environmental cues in central amygdala neurons during foraging

The paper identifies two CeA neuron populations that assign motivational properties to environmental cues and encode memory of goal location, with CeAPKC{delta} neurons specifically required for learning contextual food cues.

Tripartite extended amygdala - basal ganglia CRH circuit drives arousal and avoidance behaviour

The paper identifies a novel tripartite CRH circuit connecting extended amygdala and basal ganglia that drives arousal and avoidance behaviour through CRH receptor 1 in the substantia nigra.

Novel proteostasis reporter mouse reveals different effects of cytoplasmic and nuclear aggregates on protein quality control in neurons

The paper develops a mouse model with a proteostasis reporter to study how cytoplasmic and nuclear protein aggregates affect neuronal protein quality control in aging and disease.

Natural loss of function of ephrin-B3 shapes spinal flight circuitry in birds

This study shows that the loss of ephrin-B3 function in birds shapes spinal flight circuitry by enabling synchronous wing flapping through altered midline signaling.

Presynaptic inhibition of cutaneous afferents prevents self-generated itch

The paper identifies Ptf1a neurons in the spinal cord that inhibit cutaneous afferents, and their loss leads to chronic itch and increased skin sensitivity.

Cortical circuit alterations precede disease onset in Huntington’s disease mice

This study shows that cortical circuit alterations, including increased neuronal activity and reduced inhibitory synapses, occur before disease onset in Huntington’s disease mice.

Central Amygdala Circuits Modulate Food Consumption Through A Positive Valence Mechanism

This study identifies CeA Htr2a neurons as regulators of food consumption through positive valence mechanisms using in vivo activity manipulations and electrophysiology.