3'HS1 CTCF binding site in human β-globin locus regulates fetal hemoglobin expression
Pamela Himadewi, Xue Qing David Wang, Fan Feng, Haley Gore, Yushuai Liu, Lei Yu, Jie Liu, Ryo Kurita, Yukio Nakamura, Gerd Pfeifer, Xiaotian Zhang
The paper shows that deleting the 3HS1 CTCF binding site increases fetal hemoglobin expression in hematopoietic stem cells and erythroid progenitor cells, suggesting therapeutic potential for hemoglobinopathies.
eLife · Sep 29, 2021Peer-reviewedGenomics