Fan Feng

The paper maps the morphological and functional maturation of human endocrine pancreas from birth to age 10 using pediatric tissue samples and imaging techniques.

In 299 islet preparations from donors without diabetes, endocrine cell composition, not donor demographics, tracked insulin secretion, and δ cell percentage rose with type 2 diabetes genetic risk.

This study reports the crystal structure of a light-activated maize CRY1c-ZmGL2 complex, revealing its role in regulating cuticular wax biosynthesis through structural and biochemical analysis.

This study investigates the role of ZmCRY1s in mediating blue light regulation of epidermal wax composition and UV-B stress tolerance in maize.

The paper introduces Cleopatra, a deep learning model that predicts high-resolution 3D genome maps across human cell types, revealing cell-type-specific loops and gene regulation patterns.

The paper performs population-scale single-nucleus multi-omic profiling of skeletal muscle to identify genetic regulation across cell types and traits.

EPCOT is a deep learning framework that predicts epigenome, chromatin organization, transcriptome, and enhancer activity, showing generalizability across cell types and modalities.

The paper introduces ECHO, a graph-based deep learning model that predicts chromatin features using 3D chromatin organization, showing improved performance over sequence-based models.

The paper develops a deep learning model, CAESAR, to predict high-resolution 3D chromatin structures from epigenomic data and validates its accuracy across 91 human tissues and cell lines.

The paper shows that deleting the 3HS1 CTCF binding site increases fetal hemoglobin expression in hematopoietic stem cells and erythroid progenitor cells, suggesting therapeutic potential for hemoglobinopathies.

scHiCTools provides a computational toolbox for analyzing single-cell Hi-C data, offering methods for smoothing, embedding, clustering, and visualization of chromatin organization.

The paper investigates how 3D chromatin interactions regulate HOXA cluster genes in HSCs and leukemia by analyzing the role of the Geneless Canyon region.

The paper identifies an anti-thrombin molecule through semi-random DNA library screening and characterizes its structure and function.