Xiaotian Zhang

This paper investigates the DNA-binding properties of BCL11B's bipartite zinc finger domain and its mutations linked to neurodevelopmental disorders.

The paper identifies long Polycomb loops as a biomarker for sensitivity to Polycomb inhibition in certain cancers, particularly in AMLs with specific mutations.

This study investigates DNA methylation dynamics during lamprey embryogenesis, revealing extensive maternal-to-paternal epigenome remodeling and its link to programmed genome rearrangement.

The paper develops a deep learning model, CAESAR, to predict high-resolution 3D chromatin structures from epigenomic data and validates its accuracy across 91 human tissues and cell lines.

The paper shows that deleting the 3HS1 CTCF binding site increases fetal hemoglobin expression in hematopoietic stem cells and erythroid progenitor cells, suggesting therapeutic potential for hemoglobinopathies.

The paper identifies cell type-specific chromatin loops anchored at large DNA methylation nadirs, revealing their role in stem and progenitor cell function.

The paper investigates how 3D chromatin interactions regulate HOXA cluster genes in HSCs and leukemia by analyzing the role of the Geneless Canyon region.