First responders shape a prompt and sharp NF-κB-mediated transcriptional response to TNF-α
Samuel Zambrano, Alessia Loffreda, Elena Carelli, Giacomo Stefanelli, Federica Colombo, Édouard Bertrand, Carlo Tacchetti, A Agresti, Marco Emilio Bianchi, Nacho Molina, Davide Mazza
The paper characterizes the transcriptional response to TNF-α using single-cell analysis, showing heterogeneous gene expression with prompt and sharp population-level dynamics driven by 'first responders'.
iScience · Sep 1, 2020Peer-reviewedSystems Biology