Davide Mazza

This study shows compressive stress activates a calcium-dependent pathway that reduces translation and proteostasis through multiple mechanisms, correlating with poor survival in pancreatic cancer.

QuantiTrack, a MATLAB GUI, unifies single-molecule detection, tracking, quality control and mobility analyses; for glucocorticoid receptor, hormone washout cut bound fraction, dwell times and low-mobility occupancy.

This study shows how different Mycobacterium tuberculosis lineages interact with macrophage phenotypes to affect phagosomal acidification, highlighting the complexity of host-pathogen interactions in tuberculosis.

This study directly visualizes eukaryotic transcription factor target search in living cells and finds that efficient localization occurs near the diffusion limit without requiring facilitated diffusion, instead relying on cooperative self-interactions mediated by intrinsically disordered regions.

This study investigates how NF-κB co-activation enhances p53 accumulation dynamics, impairing DNA repair and revealing a transcriptionally mediated antagonism between p53 and NF-κB.

This study shows MYC enhances TOP2A diffusion, promoting its substrate binding and chromatin engagement, thereby stimulating topoisomerase activity.

This paper introduces a high-throughput microfluidic platform for organoid culture and multi-omics profiling, demonstrating its utility in clinical and drug discovery settings.

This study shows that MYC uses both non-specific and sequence-specific DNA binding to regulate transcription, with sequence-specific binding contributing to transcriptional activation.

The paper characterizes the transcriptional response to TNF-α using single-cell analysis, showing heterogeneous gene expression with prompt and sharp population-level dynamics driven by 'first responders'.

The paper investigates how NF-kB (p65) DNA binding time relates to transcriptional activation by analyzing mutants affecting DNA binding and protein-protein interaction domains.