Samuel Zambrano

Mycobacterium tuberculosis diversity and macrophage heterogeneity dictate phagosomal acidification

This study shows how different Mycobacterium tuberculosis lineages interact with macrophage phenotypes to affect phagosomal acidification, highlighting the complexity of host-pathogen interactions in tuberculosis.

NF-κB transcriptionally enhances p53 accumulation dynamics hampering DNA repair

This study investigates how NF-κB co-activation enhances p53 accumulation dynamics, impairing DNA repair and revealing a transcriptionally mediated antagonism between p53 and NF-κB.

A high-throughput 3D culture microfluidic platform for multi-parameter phenotypic and omics profiling of patient-derived organoids

This paper introduces a high-throughput microfluidic platform for organoid culture and multi-omics profiling, demonstrating its utility in clinical and drug discovery settings.

Small transcriptional differences among cell clones lead to distinct NF-κB dynamics

The paper shows that small transcriptional differences between cell clones lead to distinct NF-κB dynamics despite similar transcriptomic profiles.

Rapamycin mitigates Valproic Acid-induced teratogenicity in human and animal models by suppressing AP-1-mediated senescence

This study shows that rapamycin reduces VPA-induced teratogenic effects by suppressing AP-1-mediated senescence in human and zebrafish models.

First responders shape a prompt and sharp NF-κB-mediated transcriptional response to TNF-α

The paper characterizes the transcriptional response to TNF-α using single-cell analysis, showing heterogeneous gene expression with prompt and sharp population-level dynamics driven by 'first responders'.

Stochasticity and negative feedback lead to pulsed dynamics and distinct gene activity patterns

The paper investigates how stochastic gene switching and negative feedback influence gene expression dynamics, showing they can produce pulsed activity and specific time distributions.