Marco Emilio Bianchi

Neutrophil Reprogramming Underlie Vasculopathy and Lung Disease in Systemic Sclerosis

This study identifies neutrophil reprogramming in systemic sclerosis (SSc) driven by HMGB1+ extracellular vesicles, leading to lung inflammation and fibrosis, and suggests therapeutic targeting of HMGB1.

NF-κB transcriptionally enhances p53 accumulation dynamics hampering DNA repair

This study investigates how NF-κB co-activation enhances p53 accumulation dynamics, impairing DNA repair and revealing a transcriptionally mediated antagonism between p53 and NF-κB.

Hmgb2 improves astrocyte to neuron conversion by increasing the chromatin accessibility of genes associated with neuronal maturation in a proneuronal factor-dependent manner

The paper shows that Hmgb2 enhances astrocyte-to-neuron conversion by regulating chromatin accessibility of neuronal maturation genes in response to growth factors.

Small transcriptional differences among cell clones lead to distinct NF-κB dynamics

The paper shows that small transcriptional differences between cell clones lead to distinct NF-κB dynamics despite similar transcriptomic profiles.

First responders shape a prompt and sharp NF-κB-mediated transcriptional response to TNF-α

The paper characterizes the transcriptional response to TNF-α using single-cell analysis, showing heterogeneous gene expression with prompt and sharp population-level dynamics driven by 'first responders'.

Stochasticity and negative feedback lead to pulsed dynamics and distinct gene activity patterns

The paper investigates how stochastic gene switching and negative feedback influence gene expression dynamics, showing they can produce pulsed activity and specific time distributions.