Vascular endothelial growth factor receptors 1 and 3 mediate placental trophoblast leptin production in preeclampsia, inducing vascular dysfunction
Mona Elgazzaz, Safia N. Ogbi, Desmond Moronge, Elisabeth Mellott, Gibson Cooper, Kristin Backer, Amalia M. Brawley, Gabrielle Hernendez, Joanna Hitchings, Luis Valesquez Zarate, Sravankumar Kavuri, Tae Jin Lee, Daria V. Ilatovskaya, Padmashree Chaudhury Woodham, James E. Maher, , Jessica Faulkner
This study shows that sFlt-1 in preeclampsia increases trophoblast leptin production via VEGFR1 and 3, leading to vascular dysfunction.
Arteriosclerosis Thrombosis and Vascular Biology · Jul 9, 2026Peer-reviewedPhysiology